Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EDIL3, TRIM62, and ITGB3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EDIL3 grouped by Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	EDIL3 →	-3.989	-1.468	<.001	.004	3	4
SOFT_TISSUE	TRIM62 →	-0.940	-0.904	.005	.005	3	4
SOFT_TISSUE	ITGB3 →	-1.945	-0.943	.009	.003	3	4
CNS	SLC39A10 →	+1.019	+1.290	<.001	<.001	3	4
URINARY_TRACT	BPNT2 →	-1.049	-2.099	.001	<.001	3	4
PANCREAS	BAG3 →	-1.170	-1.113	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EDIL3 by Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis activity — LIVER

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