Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are F13A1, RGS8, and VGLL2, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis activity versus F13A1 in CNS (Pearson r = 0.99).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	F13A1 →	+0.071	+2.573	.001	.001	2	2
CNS	RGS8 →	+0.101	+2.573	<.001	.001	2	2
CNS	VGLL2 →	+0.116	+2.573	.004	.001	2	2
CNS	GPR34 →	+0.090	+2.573	.009	.001	2	2
CNS	MAB21L3 →	+0.050	+2.573	.006	.001	2	2
CNS	CYP2D6 →	+0.621	+2.573	.008	.001	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903589 vs F13A1 — CNS

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