Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

Across TCGA patient cohorts, RNA activity of the Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PDLIM2_S343, TERF2_S365, and C8G, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis activity versus PDLIM2_S343 in CCRCC (Pearson r = 0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PDLIM2_S343 →	+0.432	+0.065	.003	.002	3	5
UCEC	TERF2_S365 →	-0.446	-0.105	<.001	.001	3	4
UCEC	C8G →	+0.354	+0.122	.003	<.001	3	4
CCRCC	CYGB →	+0.350	+0.064	.001	<.001	3	4
LUAD	ANXA2 →	+0.252	+0.052	.003	.004	3	4
LSCC	PRPF4B →	-0.177	-0.052	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903588 vs PDLIM2_S343 — CCRCC

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