Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis

Across TCGA cell cohorts, RNA activity of the Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THBS1, TPM1, and FRMD6, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis activity versus THBS1 in LIVER (Pearson r = 0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	THBS1 →	+4.106	+0.352	.001	<.001	3	14
LIVER	TPM1 →	+2.705	+0.294	<.001	.004	3	10
LIVER	FRMD6 →	+2.735	+0.273	.002	.007	3	9
LIVER	TGFB2 →	+3.738	+0.396	<.001	<.001	3	8
STOMACH	KCNH2 →	-1.546	-0.203	.001	.003	3	8
SOFT_TISSUE	HIF1A →	+1.192	+0.231	<.001	.004	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903588 vs THBS1 — LIVER

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