Positive regulation of ATP metabolic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of ATP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABHD3, SRGAP3, and TTC39C, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of ATP metabolic process activity versus ABHD3 in CCRCC (Pearson r = -0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ABHD3 →	-0.419	-0.731	<.001	.001	3	3
CCRCC	SRGAP3 →	-0.531	-0.850	<.001	<.001	3	3
LSCC	TTC39C →	-0.334	-0.529	.002	.007	3	3
OV	RPL11P4 →	-0.098	-0.078	.004	.006	3	3
CCRCC	HM13 →	-0.474	-0.710	.002	<.001	3	2
CCRCC	CDK5RAP1 →	-0.228	-0.755	.003	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903580 vs ABHD3 — CCRCC

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