Positive regulation of ATP metabolic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of ATP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMSB4X, CDS1, and HDX, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of ATP metabolic process activity versus TMSB4X in LUNG_SCLC (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TMSB4X →	+1.723	+0.238	<.001	<.001	3	6
URINARY_TRACT	CDS1 →	-3.020	-0.306	<.001	.002	3	6
KIDNEY	HDX →	+0.917	+0.289	.001	.001	3	5
BLOOD_Lymphoma	UCHL1 →	+5.998	+0.329	<.001	<.001	3	5
SOFT_TISSUE	FST →	-3.143	-0.232	.002	.001	3	5
LUNG_NSCLC_LUAD	CRYBG2 →	-1.469	-0.261	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903580 vs TMSB4X — LUNG_SCLC

Explore this scatter interactively →