Negative regulation of ATP metabolic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of ATP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are YRDC, BZW1, and ZUP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ATP metabolic process activity versus YRDC in CCRCC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	YRDC →	-0.273	-0.155	.002	.001	3	3
CCRCC	BZW1 →	-0.239	-0.115	.001	.005	3	3
LSCC	ZUP1 →	-0.340	-0.164	.005	.009	3	3
COAD	ZSWIM5 →	+0.522	+0.128	.002	.003	2	4
COAD	UBL7-AS1 →	-0.297	-0.133	<.001	.001	3	3
OV	RPS15AP5 →	+0.937	+0.087	.005	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903579 vs YRDC — CCRCC

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