Negative regulation of ATP metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of ATP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF11, SHCBP1, and RNF182, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KIF11 grouped by Negative regulation of ATP metabolic process-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	KIF11 →	-1.716	-0.366	.002	<.001	3	4
SKIN	SHCBP1 →	-0.694	-0.803	.003	.008	3	4
URINARY_TRACT	RNF182 →	-2.724	-0.429	.008	.009	3	4
UPPER_AERODIGESTIVE_TRACT	STIL →	-1.480	-0.401	.004	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	RPP30 →	-1.091	-0.387	.003	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	FAM204A →	-0.931	-0.399	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIF11 by Negative regulation of ATP metabolic process activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →