Negative regulation of ATP metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of ATP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UPF1, PCP2, and TRIM16L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ATP metabolic process activity versus UPF1 in CNS (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	UPF1 →	+0.254	+0.194	.003	.005	3	5
LIVER	PCP2 →	+0.214	+0.237	.006	.007	3	5
STOMACH	TRIM16L →	-1.677	-0.204	.004	.009	3	4
STOMACH	HMGB3 →	-1.062	-0.318	.001	.001	3	4
LUNG_NSCLC_LUSC	ZNHIT1 →	+1.526	+0.304	<.001	.001	3	4
LUNG_SCLC	NELFB →	-0.543	-0.225	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903579 vs UPF1 — CNS

Explore this scatter interactively →