Regulation of ATP metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of ATP metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATP7A, PYCARD, and APBB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ATP metabolic process activity versus ATP7A in GBM (Pearson r = -0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ATP7A →	-0.283	-0.056	<.001	<.001	3	5
CCRCC	PYCARD →	-0.403	-0.039	.001	.002	3	4
COAD	APBB1 →	+0.543	+0.056	.003	.002	3	4
GBM	PHKB →	+0.413	+0.057	<.001	<.001	3	4
PDAC	ARVCF_S335 →	+0.468	+0.043	.001	<.001	3	4
GBM	TMF1 →	-0.178	-0.056	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903578 vs ATP7A — GBM

Explore this scatter interactively →