Regulation of ATP metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of ATP metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DNM1L_S616, DNM1L_S629, and TJP1_Y132, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ATP metabolic process activity versus DNM1L_S616 in LUAD (Pearson r = -0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DNM1L_S616 →	+0.375	+0.137	<.001	<.001	3	5
LUAD	DNM1L_S629 →	+0.375	+0.137	<.001	<.001	3	5
OV	TJP1_Y132 →	-1.346	-0.196	.002	.001	3	4
OV	TNRC6A_S943 →	+1.305	+0.168	<.001	<.001	3	3
LUAD	YARS2 →	+0.326	+0.140	<.001	<.001	3	3
UCEC	CFAP36_S85 →	+0.993	+0.163	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903578 vs DNM1L_S616 — LUAD

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