Regulation of ATP metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of ATP metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UCHL1, AIP, and SMAD9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ATP metabolic process activity versus UCHL1 in BLOOD_Lymphoma (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	UCHL1 →	+4.740	+0.217	<.001	<.001	3	6
BLOOD_Lymphoma	AIP →	+0.656	+0.182	.001	.005	3	5
LUNG_SCLC	SMAD9 →	+1.287	+0.118	.002	.008	3	5
BLOOD_Lymphoma	IER5L →	-1.776	-0.208	<.001	<.001	3	4
KIDNEY	OCEL1 →	+0.904	+0.194	.008	.009	3	4
STOMACH	LIMD2 →	+2.294	+0.167	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903578 vs UCHL1 — BLOOD_Lymphoma

Explore this scatter interactively →