Cornified envelope assembly

Across TCGA patient cohorts, RNA activity of the Cornified envelope assembly pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ACTN1, C1S, and LGALS1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cornified envelope assembly activity versus ACTN1 in COAD (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ACTN1 →	+0.565	+0.061	<.001	.004	3	7
OV	C1S →	+0.633	+0.064	<.001	.001	3	7
COAD	LGALS1 →	+0.756	+0.063	<.001	<.001	3	7
COAD	PPP1R18 →	+0.481	+0.067	<.001	<.001	3	7
COAD	COL3A1 →	+0.692	+0.083	<.001	<.001	3	7
GBM	PSTPIP1 →	+0.410	+0.072	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903575 vs ACTN1 — COAD

Explore this scatter interactively →