Cornified envelope assembly

Across TCGA cell cohorts, RNA activity of the Cornified envelope assembly pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLCD3A, PXMP2, and KCTD11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TLCD3A grouped by Cornified envelope assembly-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TLCD3A →	-0.808	-1.696	.001	<.001	3	4
LUNG_SCLC	PXMP2 →	+0.923	+0.299	.002	.009	2	5
LUNG_SCLC	KCTD11 →	-2.084	-0.318	.001	<.001	2	5
LUNG_NSCLC_LUAD	MPP1 →	-1.271	-0.624	.002	.001	3	4
CNS	CATSPER2 →	+0.902	+1.093	<.001	<.001	3	3
KIDNEY	WNT3 →	-0.841	-1.151	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TLCD3A by Cornified envelope assembly activity — KIDNEY

Explore this box plot interactively →