Cornified envelope assembly

Across TCGA cell cohorts, RNA activity of the Cornified envelope assembly pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALPK3, TAGLN3, and NPAS3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cornified envelope assembly activity versus ALPK3 in CNS (Pearson r = 0.86).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ALPK3 →	+0.338	+0.279	<.001	.002	3	2
CNS	TAGLN3 →	+2.868	+0.279	<.001	.002	3	2
CNS	NPAS3 →	+1.358	+0.265	.002	.005	3	2
CNS	NAPEPLD →	+1.731	+0.279	<.001	.002	3	2
CNS	CD47 →	+2.750	+0.381	.001	.006	3	2
CNS	FAM133B →	+0.547	+0.279	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903575 vs ALPK3 — CNS

Explore this scatter interactively →