Negative regulation of response to endoplasmic reticulum stress

Across TCGA patient cohorts, RNA activity of the Negative regulation of response to endoplasmic reticulum stress pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERBP1, ADA2, and ABI3BP, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of response to endoplasmic reticulum stress activity versus SERBP1 in HNSC (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SERBP1 →	-0.264	-0.054	<.001	.002	3	8
GBM	ADA2 →	+0.532	+0.075	<.001	<.001	3	8
BRCA	ABI3BP →	+0.867	+0.048	<.001	<.001	3	8
GBM	UTRN →	+0.301	+0.053	.008	<.001	3	7
LSCC	ADD1_S481 →	+0.604	+0.054	<.001	.005	3	7
COAD	LTBP2 →	+0.686	+0.030	<.001	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903573 vs SERBP1 — HNSC

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