Negative regulation of response to endoplasmic reticulum stress

Across TCGA cell cohorts, RNA activity of the Negative regulation of response to endoplasmic reticulum stress pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STK4, GTF3C3, and LSM14B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of response to endoplasmic reticulum stress activity versus STK4 in KIDNEY (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	STK4 →	+1.026	+0.272	.001	.004	3	5
OVARY	GTF3C3 →	+0.637	+0.155	.005	.006	3	5
PANCREAS	LSM14B →	+0.743	+0.170	<.001	.002	3	4
OVARY	FIG4 →	+0.834	+0.162	.001	.004	3	4
KIDNEY	DCAF1 →	+1.612	+0.264	.004	<.001	3	4
KIDNEY	RNPS1 →	+0.809	+0.241	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903573 vs STK4 — KIDNEY

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