Positive regulation of protein localization to cilium

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein localization to cilium pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYB5RL, ATP6V0A2, and AIF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYB5RL grouped by Positive regulation of protein localization to cilium-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CYB5RL →	-0.665	-1.206	<.001	.007	3	4
LIVER	ATP6V0A2 →	-1.560	-1.517	.002	<.001	3	4
LUNG_NSCLC_LUSC	AIF1 →	-0.224	-1.387	.002	.001	3	4
LUNG_NSCLC_LUSC	NATD1 →	-1.202	-1.264	.004	.002	3	4
KIDNEY	ALDOC →	+4.380	+1.704	.002	.008	3	4
SKIN	CANX →	-0.800	-1.474	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYB5RL by Positive regulation of protein localization to cilium activity — SOFT_TISSUE

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