Positive regulation of protein localization to cilium

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein localization to cilium pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CROCC, CCDC88A, and PRSS53, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of protein localization to cilium activity versus CROCC in SOFT_TISSUE (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CROCC →	+1.795	+0.119	<.001	<.001	3	17
BREAST	CCDC88A →	+2.721	+0.174	<.001	<.001	3	15
BONE	PRSS53 →	+1.024	+0.140	<.001	<.001	3	14
SOFT_TISSUE	KRI1 →	+0.810	+0.085	<.001	<.001	3	13
BONE	CEP131 →	+1.183	+0.128	<.001	<.001	3	13
BONE	ILF3 →	+1.048	+0.125	.003	.002	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903566 vs CROCC — SOFT_TISSUE

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