Regulation of protein localization to cilium

Across TCGA patient cohorts, RNA activity of the Regulation of protein localization to cilium pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STK36, S100A16, and TPTE2P5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to cilium activity versus STK36 in GBM (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	STK36 →	+0.329	+0.210	<.001	.005	3	4
UCEC	S100A16 →	-0.833	-0.470	.001	.005	2	5
COAD	TPTE2P5 →	+0.424	+0.574	.002	.007	3	4
BRCA	TMEM86A →	-0.929	-0.587	<.001	.002	3	3
GBM	SLC45A3 →	-0.784	-0.381	.005	.001	3	3
GBM	TSPAN15 →	-0.599	-0.329	.006	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903564 vs STK36 — GBM

Explore this scatter interactively →