Regulation of protein localization to cilium

Across TCGA cell cohorts, RNA activity of the Regulation of protein localization to cilium pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LZTFL1, GSK3B, and DLD, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LZTFL1 grouped by Regulation of protein localization to cilium-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LZTFL1 →	-0.288	-2.111	.003	<.001	3	7
BLOOD_Myeloma	GSK3B →	-0.338	-1.523	<.001	.002	2	7
BLOOD_Leukemia	DLD →	+0.121	+0.895	.005	.004	3	5
BLOOD_Leukemia	CHRM1 →	-0.203	-0.852	<.001	.006	3	4
STOMACH	KCNJ3 →	-0.218	-1.281	.002	.002	3	4
BLOOD_Lymphoma	GLRX →	+0.222	+1.924	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LZTFL1 by Regulation of protein localization to cilium activity — LARGE_INTESTINE

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