Regulation of protein localization to cilium

Across TCGA cell cohorts, RNA activity of the Regulation of protein localization to cilium pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MECOM, HNRNPLL, and S100A14, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MECOM grouped by Regulation of protein localization to cilium-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MECOM →	+1.982	+0.794	.005	.001	3	5
LARGE_INTESTINE	HNRNPLL →	-0.490	-1.385	.001	.001	3	5
LUNG_NSCLC_LUSC	S100A14 →	+4.480	+1.214	<.001	<.001	3	5
SKIN	IFT20 →	+0.714	+1.176	.001	.001	3	4
CNS	JUP →	+2.237	+0.813	.007	.006	3	4
PANCREAS	SAA1 →	+5.583	+1.476	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MECOM by Regulation of protein localization to cilium activity — BLOOD_Leukemia

Explore this box plot interactively →