Regulation of protein localization to cilium

Across TCGA cell cohorts, RNA activity of the Regulation of protein localization to cilium pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOMM20, ASB13, and SLC25A13, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to cilium activity versus TOMM20 in LUNG_NSCLC_LUSC (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TOMM20 →	+1.021	+1.379	.001	<.001	3	4
LUNG_NSCLC_LUSC	ASB13 →	+1.247	+1.737	.005	<.001	3	4
BLOOD_Leukemia	SLC25A13 →	-1.328	-0.242	<.001	<.001	3	3
BLOOD_Leukemia	PER3 →	-1.085	-0.183	<.001	.001	3	3
SOFT_TISSUE	SKAP2 →	-2.632	-0.246	.005	<.001	3	3
BLOOD_Leukemia	PTPN3 →	+1.887	+0.243	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903564 vs TOMM20 — LUNG_NSCLC_LUSC

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