Positive regulation of tumor necrosis factor superfamily cytokine production

Across TCGA cell cohorts, RNA activity of the Positive regulation of tumor necrosis factor superfamily cytokine production pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GCG, FTL, and DMAC1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GCG grouped by Positive regulation of tumor necrosis factor superfamily cytokine production-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GCG →	+0.188	+0.303	<.001	<.001	3	4
BLOOD_Lymphoma	FTL →	+1.761	+0.296	.003	.002	3	4
KIDNEY	DMAC1 →	-0.947	-0.277	<.001	.001	3	3
LUNG_NSCLC_LUAD	TCAP →	+0.674	+0.174	.003	.002	3	3
LUNG_NSCLC_LUAD	EEF1G →	+0.428	+0.165	.001	<.001	3	3
STOMACH	YIPF2 →	+0.927	+0.321	<.001	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GCG by Positive regulation of tumor necrosis factor superfamily cytokine production activity — PANCREAS

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