Positive regulation of exosomal secretion

Across TCGA patient cohorts, RNA activity of the Positive regulation of exosomal secretion pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP34, ADCY7, and DYNC1LI2, each associated with the pathway in up to 30 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of exosomal secretion activity versus USP34 in DLBC (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	USP34 →	+1.904	+0.077	<.001	<.001	3	30
DLBC	ADCY7 →	+1.541	+0.075	<.001	<.001	3	30
DLBC	DYNC1LI2 →	+1.803	+0.086	<.001	<.001	3	30
DLBC	MIR5581 →	+1.353	+0.075	<.001	<.001	3	30
DLBC	AGO4 →	+1.183	+0.075	<.001	<.001	3	29
UVM	GCC2 →	+1.385	+0.066	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903543 vs USP34 — DLBC

Explore this scatter interactively →