Positive regulation of exosomal secretion

Across TCGA patient cohorts, RNA activity of the Positive regulation of exosomal secretion pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1B, TAP1, and MAP1B_S1378, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of exosomal secretion activity versus MAP1B in LSCC (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP1B →	+0.702	+0.042	.008	.006	2	7
HNSC	TAP1 →	-0.449	-0.075	.001	.001	3	5
PDAC	MAP1B_S1378 →	+0.327	+0.032	.004	.003	3	5
LSCC	MED10 →	+0.273	+0.069	<.001	<.001	3	5
LUAD	PRAM1_S298 →	-0.531	-0.038	<.001	.003	3	5
LSCC	SSR3_S105 →	-0.807	-0.045	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903543 vs MAP1B — LSCC

Explore this scatter interactively →