Positive regulation of exosomal secretion

Across TCGA patient cohorts, RNA activity of the Positive regulation of exosomal secretion pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXCR2, CXCR1, and C11orf94, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of exosomal secretion activity versus CXCR2 in UCEC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CXCR2 →	+0.953	+0.155	<.001	.003	3	6
LSCC	CXCR1 →	+0.778	+0.165	.002	<.001	3	6
OV	C11orf94 →	-0.238	-0.125	.006	.004	3	5
GBM	HNRNPA1P2 →	-0.613	-0.149	<.001	<.001	3	4
LSCC	IL1RN →	+1.056	+0.135	.003	.007	3	4
PDAC	PDZK1IP1 →	+0.787	+0.122	.003	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903543 vs CXCR2 — UCEC

Explore this scatter interactively →