Positive regulation of exosomal secretion

Across TCGA cell cohorts, RNA activity of the Positive regulation of exosomal secretion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGO2, MFSD4A, and CAV2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AGO2 grouped by Positive regulation of exosomal secretion-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	AGO2 →	+0.928	+0.188	.001	<.001	3	5
LUNG_NSCLC_LUSC	MFSD4A →	+0.513	+0.160	.008	.007	3	5
PANCREAS	CAV2 →	+1.601	+0.298	.002	<.001	3	4
LARGE_INTESTINE	SH3TC2 →	+1.351	+0.279	.001	.005	3	4
LARGE_INTESTINE	FBXO16 →	-0.698	-0.306	.004	.004	3	4
OESOPHAGUS	PLEKHA8 →	+0.685	+0.260	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AGO2 by Positive regulation of exosomal secretion activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →