Regulation of exosomal secretion

Across TCGA patient cohorts, RNA activity of the Regulation of exosomal secretion pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FNDC3A_S203, ARHGAP15_S43, and SSR3_S105, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of exosomal secretion activity versus FNDC3A_S203 in LSCC (Pearson r = -0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FNDC3A_S203 →	-0.458	-0.056	<.001	<.001	3	5
HNSC	ARHGAP15_S43 →	-0.454	-0.074	.005	<.001	3	4
LSCC	SSR3_S105 →	-0.631	-0.040	.002	.003	3	4
BRCA	HTRA3 →	+0.477	+0.029	.002	.002	3	4
LSCC	U2SURP_S202 →	+0.837	+0.052	<.001	.002	3	4
LSCC	CBX5_S110 →	-0.873	-0.048	<.001	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903541 vs FNDC3A_S203 — LSCC

Explore this scatter interactively →