Regulation of exosomal secretion

Across TCGA patient cohorts, RNA activity of the Regulation of exosomal secretion pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CXCR1, SMC2-AS1, and POLR1E, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of exosomal secretion activity versus CXCR1 in PDAC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CXCR1 →	+0.787	+0.163	<.001	.001	3	5
OV	SMC2-AS1 →	-0.171	-0.188	.002	<.001	3	4
COAD	POLR1E →	-0.359	-0.194	.007	.002	3	4
LSCC	TMEM184A →	+0.792	+0.147	<.001	<.001	3	4
LSCC	CES2 →	+0.494	+0.158	<.001	<.001	3	4
BRCA	CMTR2 →	+0.671	+0.177	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903541 vs CXCR1 — PDAC

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