Regulation of exosomal secretion

Across TCGA cell cohorts, RNA activity of the Regulation of exosomal secretion pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VPS37B, FAM220A, and FGF2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VPS37B grouped by Regulation of exosomal secretion-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	VPS37B →	+0.916	+0.503	<.001	.006	2	6
OESOPHAGUS	FAM220A →	+0.569	+0.261	.004	.003	3	5
SOFT_TISSUE	FGF2 →	+2.647	+0.281	.005	.001	3	4
LUNG_NSCLC_LUAD	EPCAM →	+2.199	+0.369	.002	.004	3	4
SKIN	MIGA2 →	+0.256	+0.156	.001	.005	3	4
SKIN	RP9 →	+0.594	+0.169	.001	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VPS37B by Regulation of exosomal secretion activity — BREAST

Explore this box plot interactively →