Regulation of exosomal secretion

Across TCGA cell cohorts, RNA activity of the Regulation of exosomal secretion pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERINC3, SDC4, and ATP13A2, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of exosomal secretion activity versus SERINC3 in BONE (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SERINC3 →	+1.412	+0.142	<.001	<.001	3	15
SOFT_TISSUE	SDC4 →	+2.986	+0.082	<.001	.003	3	13
OVARY	ATP13A2 →	+1.106	+0.132	<.001	<.001	3	13
LARGE_INTESTINE	VPS4B →	+0.937	+0.103	<.001	<.001	3	13
PANCREAS	SERINC2 →	+2.076	+0.099	<.001	<.001	3	13
OVARY	CPTP →	+0.982	+0.101	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903541 vs SERINC3 — BONE

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