Regulation of exosomal secretion

Across TCGA cell cohorts, RNA activity of the Regulation of exosomal secretion pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LONP2, VAC14, and RCBTB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of exosomal secretion activity versus LONP2 in SKIN (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	LONP2 →	+0.962	+0.387	<.001	<.001	3	5
SKIN	VAC14 →	+0.674	+0.308	<.001	<.001	2	5
SKIN	RCBTB1 →	+0.797	+0.262	.007	.005	3	4
UPPER_AERODIGESTIVE_TRACT	CYB5RL →	+0.928	+0.162	.005	.009	2	5
CNS	SCFD2 →	+0.706	+0.203	<.001	.001	3	4
BREAST	ARHGAP18 →	+1.076	+0.163	.006	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903541 vs LONP2 — SKIN

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