Meiotic cell cycle process involved in oocyte maturation

Across TCGA patient cohorts, RNA activity of the Meiotic cell cycle process involved in oocyte maturation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CFL1P4, RPS23P2, and MRPS21P1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic cell cycle process involved in oocyte maturation activity versus CFL1P4 in BRCA (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CFL1P4 →	-0.898	-0.245	.002	.004	3	4
BRCA	RPS23P2 →	-1.113	-0.248	<.001	.003	3	3
BRCA	MRPS21P1 →	-1.106	-0.222	.002	.001	3	3
BRCA	RPL36AP41 →	-1.316	-0.220	<.001	.003	3	3
BRCA	RNU7-151P →	-0.750	-0.201	.008	.006	3	3
BRCA	FTH1P13 →	-0.398	-0.134	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903537 vs CFL1P4 — BRCA

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