Meiotic cell cycle process involved in oocyte maturation

Across TCGA patient cohorts, RNA activity of the Meiotic cell cycle process involved in oocyte maturation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CHGB_S149, RMDN3_S50, and SMARCAD1_S132, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic cell cycle process involved in oocyte maturation activity versus CHGB_S149 in BRCA (Pearson r = 0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CHGB_S149 →	+1.883	+0.172	<.001	<.001	3	3
HNSC	RMDN3_S50 →	-1.099	-0.549	<.001	<.001	3	2
COAD	SMARCAD1_S132 →	+0.460	+0.124	<.001	.001	3	2
OV	TBC1D2B_T277 →	-2.724	-0.890	<.001	<.001	3	2
BRCA	TP53INP1_S156 →	-0.780	-0.092	.002	<.001	2	3
HNSC	TRAK2_T776 →	-1.651	-0.411	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903537 vs CHGB_S149 — BRCA

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