Meiotic cell cycle process involved in oocyte maturation

Across TCGA cell cohorts, RNA activity of the Meiotic cell cycle process involved in oocyte maturation pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP2R1A, TRABD, and MAPK9, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP2R1A grouped by Meiotic cell cycle process involved in oocyte maturation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PPP2R1A →	-0.582	-0.202	<.001	<.001	3	10
BREAST	TRABD →	+0.209	+0.184	.001	.004	3	4
BREAST	MAPK9 →	-0.172	-0.204	.003	.009	3	4
LUNG_NSCLC_LUAD	COPE →	+0.235	+0.151	.005	.009	3	4
SOFT_TISSUE	GLRX →	-0.140	-0.215	.008	<.001	3	4
KIDNEY	SEMA3F →	-0.136	-0.163	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP2R1A by Meiotic cell cycle process involved in oocyte maturation activity — BREAST

Explore this box plot interactively →