Meiotic cell cycle process involved in oocyte maturation

Across TCGA cell cohorts, RNA activity of the Meiotic cell cycle process involved in oocyte maturation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC42BPG, SMARCD3, and TTC5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDC42BPG grouped by Meiotic cell cycle process involved in oocyte maturation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CDC42BPG →	-2.178	-0.821	<.001	.002	3	4
KIDNEY	SMARCD3 →	+1.775	+1.700	<.001	.001	3	4
CNS	TTC5 →	+0.502	+0.823	.008	.007	3	3
CNS	ATXN2L →	+0.577	+0.892	.005	.009	3	3
CNS	PAGR1 →	+0.663	+1.230	.006	<.001	3	3
LARGE_INTESTINE	ZNF25 →	+0.685	+0.746	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDC42BPG by Meiotic cell cycle process involved in oocyte maturation activity — LUNG_SCLC

Explore this box plot interactively →