Regulation of protein targeting

Across TCGA patient cohorts, RNA activity of the Regulation of protein targeting pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HPGDS, RPL5, and SETD7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein targeting activity versus HPGDS in LSCC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HPGDS →	+0.424	+0.039	<.001	.001	3	6
GBM	RPL5 →	-0.199	-0.046	.002	<.001	3	5
COAD	SETD7 →	+0.303	+0.015	.004	.003	3	5
GBM	SFXN3 →	+0.236	+0.039	.007	.001	3	5
BRCA	CAPG_S129 →	+0.611	+0.022	.005	.005	3	5
GBM	SEPTIN4_S432 →	+0.969	+0.051	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903533 vs HPGDS — LSCC

Explore this scatter interactively →