Regulation of membrane tubulation

Across TCGA patient cohorts, RNA activity of the Regulation of membrane tubulation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CARM1, SPP1_S234, and SPP1_S280, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of membrane tubulation activity versus CARM1 in LSCC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CARM1 →	+0.206	+0.033	<.001	<.001	3	5
LUAD	SPP1_S234 →	+1.222	+0.050	<.001	.001	3	4
LUAD	SPP1_S280 →	+0.964	+0.051	<.001	<.001	3	4
LUAD	SPP1_S62 →	+1.400	+0.058	<.001	.002	3	4
CCRCC	CFHR3 →	+0.451	+0.029	<.001	.005	3	4
BRCA	COPB1 →	-0.176	-0.058	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903525 vs CARM1 — LSCC

Explore this scatter interactively →