Regulation of membrane tubulation

Across TCGA patient cohorts, RNA activity of the Regulation of membrane tubulation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FRZB, PTTG1, and KNL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of membrane tubulation activity versus FRZB in LUAD (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FRZB →	+0.750	+0.218	<.001	<.001	3	6
LUAD	PTTG1 →	-0.649	-0.251	.007	.002	3	6
PDAC	KNL1 →	-0.737	-0.224	<.001	<.001	3	6
PDAC	CENPN →	-0.471	-0.190	<.001	.001	3	6
LSCC	ZBTB16 →	+0.976	+0.407	<.001	.002	3	5
BRCA	DNAJC9 →	-0.362	-0.145	.009	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903525 vs FRZB — LUAD

Explore this scatter interactively →