Regulation of membrane tubulation

Across TCGA cell cohorts, RNA activity of the Regulation of membrane tubulation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KCNE5, AHNAK2, and FRAT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KCNE5 grouped by Regulation of membrane tubulation-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KCNE5 →	-0.392	-0.385	.001	.009	3	5
BLOOD_Myeloma	AHNAK2 →	-0.225	-0.272	.001	.007	3	4
PANCREAS	FRAT1 →	-0.695	-0.319	.006	.004	3	4
OVARY	ZNF490 →	-0.612	-0.330	.003	.004	3	3
BLOOD_Myeloma	MSX1 →	-0.899	-0.405	<.001	.003	3	3
BLOOD_Myeloma	TNFRSF1B →	-4.143	-0.389	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KCNE5 by Regulation of membrane tubulation activity — BLOOD_Lymphoma

Explore this box plot interactively →