Regulation of membrane tubulation

Across TCGA cell cohorts, RNA activity of the Regulation of membrane tubulation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRYL1, KLK8, and SEMA7A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of membrane tubulation activity versus CRYL1 in LUNG_NSCLC_LUAD (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CRYL1 →	+0.878	+1.002	.009	.002	3	5
OVARY	KLK8 →	-5.122	-1.411	<.001	<.001	3	4
SKIN	SEMA7A →	-1.606	-0.901	.001	.006	3	4
SKIN	HIGD1A →	+0.642	+1.131	.001	.001	3	4
SKIN	CDCA2 →	+0.667	+0.960	<.001	<.001	3	4
OVARY	MEST →	-3.432	-1.588	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903525 vs CRYL1 — LUNG_NSCLC_LUAD

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