Positive regulation of blood circulation

Across TCGA patient cohorts, RNA activity of the Positive regulation of blood circulation pathway is significantly associated with the RNA expression of multiple genes, with the TGCT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ETS2, EDN1, and SLC1A1, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of blood circulation activity versus ETS2 in TGCT (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	ETS2 →	+1.236	+0.034	<.001	<.001	3	19
TGCT	EDN1 →	+1.196	+0.035	<.001	<.001	3	18
ESCA	SLC1A1 →	+1.210	+0.028	<.001	<.001	2	18
UCS	ADM →	+1.366	+0.029	.003	.006	1	19
UCS	EDN2 →	+1.519	+0.025	.003	.002	2	17
TGCT	CCN1 →	+1.338	+0.036	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903524 vs ETS2 — TGCT

Explore this scatter interactively →