Positive regulation of blood circulation

Across TCGA patient cohorts, RNA activity of the Positive regulation of blood circulation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HHATL, AKR1B10, and GTF2E1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of blood circulation activity versus HHATL in HNSC (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HHATL →	+1.287	+0.495	<.001	<.001	3	4
PDAC	AKR1B10 →	+1.585	+0.251	<.001	.006	3	4
PDAC	GTF2E1 →	-0.275	-0.290	.001	<.001	3	4
LSCC	CNTN5 →	+0.485	+0.059	.003	<.001	3	3
LSCC	CA8 →	+0.721	+0.067	.008	.002	3	3
BRCA	PRKAA2 →	+1.131	+0.086	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903524 vs HHATL — HNSC

Explore this scatter interactively →