Positive regulation of blood circulation

Across TCGA patient cohorts, RNA activity of the Positive regulation of blood circulation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATP1B1, CYP20A1, and NDUFB6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of blood circulation activity versus ATP1B1 in BRCA (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ATP1B1 →	+0.668	+0.100	<.001	<.001	3	5
UCEC	CYP20A1 →	+0.609	+0.278	<.001	.006	3	4
COAD	NDUFB6 →	+0.378	+0.213	<.001	<.001	3	4
BRCA	PRKAA2_S377 →	+0.829	+0.108	<.001	<.001	3	4
GBM	ACTL6A →	-0.270	-0.746	<.001	<.001	3	4
PDAC	OMA1 →	+0.489	+0.262	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903524 vs ATP1B1 — BRCA

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