Negative regulation of blood circulation

Across TCGA cell cohorts, RNA activity of the Negative regulation of blood circulation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are F7, PPP1R7, and ITPR2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, F7 grouped by Negative regulation of blood circulation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	F7 →	-0.183	-0.184	.001	.003	3	3
LUNG_NSCLC_LUAD	PPP1R7 →	+0.146	+0.774	.006	<.001	3	3
SKIN	ITPR2 →	-0.291	-0.270	.001	.001	3	3
OESOPHAGUS	RUNDC3A →	+0.155	+1.210	.009	.001	3	3
OESOPHAGUS	C12orf40 →	-0.159	-1.552	.001	.001	3	3
BREAST	MYADML2 →	+0.433	+0.228	.003	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

F7 by Negative regulation of blood circulation activity — LUNG_SCLC

Explore this box plot interactively →