Regulation of blood circulation

Across TCGA patient cohorts, RNA activity of the Regulation of blood circulation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DKKL1, KHDC1, and ITM2B, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of blood circulation activity versus DKKL1 in OV (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DKKL1 →	-1.336	-0.136	.001	<.001	3	1
OV	KHDC1 →	-1.533	-0.099	<.001	.006	3	1
OV	ITM2B →	+0.687	+0.098	.003	.007	3	1
OV	ZC3H8 →	-0.637	-0.103	.007	.004	3	1
OV	AKR7A3 →	-1.110	-0.143	.005	.003	3	1
OV	LINC01116 →	-1.544	-0.118	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903522 vs DKKL1 — OV

Explore this scatter interactively →