Regulation of blood circulation

Across TCGA cell cohorts, RNA activity of the Regulation of blood circulation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYOF, SAMD9, and PSMB8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of blood circulation activity versus MYOF in BONE (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MYOF →	+5.079	+0.276	.007	.008	3	6
BONE	SAMD9 →	+1.789	+0.239	.001	.001	3	6
BREAST	PSMB8 →	+2.311	+0.165	.001	.005	3	6
LUNG_SCLC	SP100 →	+2.056	+0.199	.004	.008	3	6
BONE	APOL1 →	+2.642	+0.259	.007	.003	2	6
PANCREAS	PALD1 →	-1.502	-0.240	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903522 vs MYOF — BONE

Explore this scatter interactively →