Endoplasmic reticulum to cytosol transport

Across TCGA patient cohorts, RNA activity of the Endoplasmic reticulum to cytosol transport pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR35, SPTAN1, and UACA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endoplasmic reticulum to cytosol transport activity versus WDR35 in PDAC (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	WDR35 →	-0.375	-0.164	<.001	.002	3	6
HNSC	SPTAN1 →	-0.428	-0.126	.001	.006	3	6
PDAC	UACA →	-0.410	-0.211	.002	<.001	3	6
CCRCC	DOCK1 →	-0.384	-0.281	.001	.001	3	6
CCRCC	HSPG2 →	-0.815	-0.234	<.001	.003	3	5
HNSC	AMOTL1 →	-0.714	-0.175	.006	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903513 vs WDR35 — PDAC

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