Liposaccharide metabolic process

Across TCGA patient cohorts, RNA activity of the Liposaccharide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are E2F5, C2orf66, and PCDHGA6, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Liposaccharide metabolic process activity versus E2F5 in BRCA (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	E2F5 →	-0.464	-0.195	.002	<.001	3	3
BRCA	C2orf66 →	+0.335	+0.159	.002	<.001	3	3
LSCC	PCDHGA6 →	-0.672	-0.123	<.001	.005	3	3
COAD	SPZ1 →	+0.150	+0.175	.001	.002	3	3
COAD	ZNF804A →	-0.159	-0.155	.002	.001	3	3
COAD	MICE →	+0.612	+0.201	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903509 vs E2F5 — BRCA

Explore this scatter interactively →